ESTD PERPUSTAKAAN UNTAD
ESTD PERPUSTAKAAN UNTAD
| JudulKORELASI ANTARA KADAR PROSTATE SPECIFIC ANTIGEN (PSA) TOTAL DENGAN GLEASON SCORE PADA PASIEN KARSINOMA PROSTAT DI RSUD UNDATA PALU |
| Nama: LASMAN L. M RADJABANI |
| Tahun: 2022 |
| Abstrak KORELASI ANTARA KADAR PROSTATE SPECIFIC ANTIGEN (PSA) DAN SKOR GLEASON PADA KARSINOMA PROSTAT PASIEN DI RUMAH SAKIT UNDATA PALU Lasman L.M. Radjabani*, M. Sabir*, Aristo Bundu* * Program Studi Kedokteran, Fakultas Kedokteran, Tadulako. Universitas ** Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Tadulako *** Bagian Bedah Urologi, Fakultas Kedokteran, Universitas Tadulako ABSTRAK Latar Belakang: Karsinoma prostat merupakan kanker kedua yang paling sering didiagnosis pada pria setelah kanker paru. Jenis kanker prostat yang paling umum adalah kanker prostat. Dalam mendiagnosis kanker prostat, kadar PSA (Prostate-Specific Antigen) sering digunakan. Tes tingkat PSA juga dapat digunakan untuk memantau perkembangan kanker prostat. Sedangkan dalam menentukan prognosis sering digunakan sistem skor Gleason berdasarkan gambaran histopatologi. Tujuan Penelitian: Untuk mengetahui hubungan kadar Prostate Specific Antigen (PSA) total dengan skor Gleason pada pasien kanker prostat. Metode Penelitian: Desain penelitian yang digunakan adalah penelitian kuantitatif dengan metode penelitian deskriptif analitik yang menggunakan pendekatan cross sectional dengan data sekunder berupa data rekam medis. Penelitian dilaksanakan di Rumah Sakit Umum Daerah Undata Kota Palu pada bulan Januari 2022. Teknik pengambilan sampel adalah purposive sampling dengan jumlah sampel sebanyak 35 kasus. Data dianalisis dengan uji korelasi Spearman. Hasil: Angka kejadian karsinoma prostat di RSUD Undata berdasarkan rentang usia, penderita karsinoma prostat lebih banyak ditemukan pada kelompok umur 50 tahun yaitu 24 kasus (68,5%). Pasien karsinoma prostat didominasi oleh pasien dengan kadar PSA 4 yaitu 26 kasus (74,2%). Derajat histopatologi karsinoma prostat yang paling banyak ditemukan adalah pada kelompok High Gleason Score yaitu sebanyak 26 kasus (74,2%). Berdasarkan perhitungan statistik menggunakan uji korelasi Spearman, p = 0,03 (p Kesimpulan: Terdapat hubungan yang bermakna antara kadar PSA dengan derajat histopatologis Gleason Score pada pasien kanker prostat. Kata kunci: Karsinoma prostat; tingkat PSA; Skor Gleason. CORRELATION BETWEEN PROSTATE SPECIFIC ANTIGEN (PSA) LEVELS AND GLEASON SCORE IN PROSTATE CARCINOMA PATIENTS IN UNDATA PALU HOSPITAL Lasman L.M. Radjabani*, M. Sabir*, Aristo Bundu* * Medical Studies Program, Faculty of Medicine, Tadulako. University ** Department of Microbiology, Faculty of Medicine, Tadulako University *** Department of Urological Surgery, Faculty of Medicine, Tadulako University ABSTRACT Background: Prostate carcinoma is the second most frequently diagnosed cancer in men after lung cancer. The most common type of prostate cancer is prostate cancer. In diagnosing prostate cancer, PSA (Prostate-Specific Antigen) levels are often used. The PSA level test can also be used to monitor the progression of prostate cancer. Meanwhile, in determining the prognosis, the Gleason score system is often used based on the histopathological picture. The objective of The Research: To determine the correlation between total Prostate Specific Antigen (PSA) levels with Gleason score in prostate cancer patients. Research Methods: The research design used is quantitative research with an analytical descriptive research method that uses a cross-sectional approach with secondary data in the form of medical record data. The research was carried out at the Undata Regional General Hospital, Palu City in January 2022. The sampling technique was purposive sampling with a sample of 35 cases. Data were analyzed by the Spearman correlation test. Result: The incidence of prostate carcinoma in Undata Hospital based on age range, patients with prostate carcinoma were found more in the 50 year age group, namely 24 cases (68.5%). Prostate carcinoma patients were dominated by patients with PSA levels 4, namely 26 cases (74.2%). The histopathological degree of prostate carcinoma that was more commonly found was in the High Gleason Score group, which was 26 cases (74,2%). Based on statistical calculations using the Spearman correlation test, p = 0.03 (p Conclusion: There is a significant correlation between PSA levels and the histopathological degree of Gleason Score in prostate cancer patients. Keywords: Prostate carcinoma; PSA levels; Gleason Score. |