ESTD PERPUSTAKAAN UNTAD
ESTD PERPUSTAKAAN UNTAD
| JudulEFEK GASTROPROTEKTIF EKSTRAK KULIT BATANG PEPOLO (Bischofia Javanica Blume) PADA TIKUS PUTIH (Rattus Norvegicus) JANTAN YANG DIINDUKSI ASPIRIN |
| Nama: RINI SAPUTRI |
| Tahun: 2021 |
| Abstrak Prolonged use of nonsteroidal anti-inflammatory drugs (NSAIDs) can trigger injury/ulcers and bleed in the gastric mucosa. One plant that has the potential to be a gastroprotective is the stem bark of pepolo. Pepolo stem bark (Bischofia javanica Blume) is empirically used for the treatment of peptic ulcers. It contains secondary metabolites such as flavonoids that can increase the production of prostaglandins and reduce the secretion of acids, tannins that can form a protective layer of the gastric mucosa. This study aims to determine the effect of gastroprotective pepolo stem bark extract (Bischofia javanica Blume) against gastric ulcers of white male rats (Rattus norvegicus) induced by Aspirin. The study used 24 rats grouped into six groups at random. Normal group (Na CMC 0.5%), negative group (Na CMC 0.5% + aspirin induction), positive group (omeprazole 3.6 mg/kg BW + aspirin induction), pepolo stem bark extract group 100 mg/kg BW + aspirin induction, pepolo bark extract group 200 mg/kg BW + aspirin induction, and pepolo bark extract group 300 mg/kg BW + aspirin induction. The treatment was given orally for eight days. On the 9th day, the mice were dissected and tested on the stomach organs. The parameters measured were scores based on the severity of rat peptic ulcers, ulceration index, and percentage protection ratio. The scoring data were analyzed using the non-parametric Kruskal Wallis test and the Mann-Whitney advanced test. The average ulcer score for the normal control group, negative control, positive control, and ethanol extract at doses of 100, 200 and 300 mg/kg BW was 0.00, respectively; 0,00; 5,75; 0,00; 4,33; 0,00; and 0,00 with a percentage of 100% successive ulcer healing rates; 100%; 0%; 100%; 24,69%; 100%; and 100%. Based on the study results, the extract of pepolo stem bark at a dose of 200 mg/kg BW is the best dose that can provide activity as an anti-peptic ulcer with a percent ulcer healing rate of 100%. |